Tau: The Center of a Signaling Nexus in Alzheimer's Disease
نویسندگان
چکیده
Tau is a microtubule-associated protein whose misfolding, hyper-phosphorylation, loss of normal function and toxic gain of function are linked to several neurodegenerative disorders, including Alzheimer's disease (AD). This review discusses the role of tau in amyloid-β (Aβ) induced toxicity in AD. The consequences of tau dysfunction, starting from the axon and concluding at somadendritic compartments, will be highlighted.
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عنوان ژورنال:
- Frontiers in neuroscience
دوره 10 شماره
صفحات -
تاریخ انتشار 2016